Put a chest and the items you want to delete in your inventory.

Second Step

Visit Pelican Town after preparing everything and get yourself a victim.

(I chose Kent but its up to you)

Third Step

Place the chest in the path of your victim. (could be right in front of a house or anywhere you want)

Put all your items you want to delete inside the chest.

Warning: Last Chance to save Items you don’t want to delete. (of course reloading your world would fix mistakes easily)

Last Step

Hide yourself and wait for your victim to walk through your chest. (not really necessary, you could leave if you want)

Your Items are now gone forever!